Human study tracks brain’s glymphatic flow in real time, opening Alzheimer’s drug avenues
May 27, 2025
News & Publications
Publications & Presentations
The glymphatic system clears amyloid beta and tau from brain to plasma in humans
Paul Dagum, Donald L. Elbert, Laurent Giovangrandi, Tarandeep Singh, Venky V. Venkatesh, Alejandro Corbellini, Robert M. Kaplan, Swati Rane Levendovszky, Elizabeth Ludington, Kevin Yarasheski, Jeffrey Lowenkron, Carla VandeWeerd, Miranda M. Lim, Jeffrey J. Iliff
October, 2025
Nature Biomedical Engineering -- A wireless device for continuous measurement of brain parenchymal resistance tracks glymphatic function in humans
Paul Dagum, Laurent Giovangrandi, Swati Rane Levendovszky, Jake J. Winebaum, Tarandeep Singh, Yeilim Cho, Robert M. Kaplan, Michael S. Jaffee, Miranda M. Lim, Carla Vandeweerd and Jeffrey J. Iliff
May, 2025
Glymphatic flow resistance in humans measured by multifrequency impedance dispersion
Paul Dagum, Laurent Giovangrandi, Swati Rane Levendovszky, Jake J. Winebaum, Tarandeep Singh, Yeilim Cho, Robert M. Kaplan, Michael S. Jaffee, Miranda M. Lim, Carla Vandeweerd, Jeffrey J. Iliff
September, 2024
SLEEP 2024 - Measuring the Resistance to Glymphatic Flow in Humans
Paul Dagum
June, 2024
MHSRS 2023 - Development and Validation of a Wearable Device for Continuous Assessment and Measurement of Sleep-Associated Cranial Fluid Dynamics and EEG
Paul Dagum, Laurent Giovangrandi, Jacob Winebaum, Juan Piantino, Miranda M. Lim, Jeffrey Iliff
August, 2023
AAIC 2023 - Comparison of IVIM MRI measures of brain fluid transport against contrast-enhanced MRI in the setting of sleep deprivation
Swati Rane, Carla Vanderweerd, Mitchell Roberts, Tarandeep Singh, Alejandro Corbellini, Cole Anderson, Juan Piantino, Miranda M. Lim, Paul Dagum, Jeffrey Iliff
July 2023
AAIC 2023 - Noninvasive and remote measurement of sleep-active glymphatic function in the human brain by dynamic impedance spectro-tomography
Jeffrey Iliff, Swati Rane Levendovszky, Carla Vanderweerd, Michael Jaffe, Jeffrey Lowenkron, Tarandeep Singh, Laurent Giovangrandi, Miranda M. Lim, Paul Dagum
July 2023
SLEEP 2023 - A wearable device for continuous assessment and measurement of sleep cranial fluid dynamics and EEG
Laurent Giovangrandi, Shilpa Balakrishnan, Juan Piantino, Miranda M Lim, Jeffrey Iliff, Paul Dagum
June 2023